ea0041ep730 | Neuroendocrinology | ECE2016
Gutkowska Jolanta
, Plante Eric
, Menouar Ahmed
, Danalache Bogdan
, Jankowski Marek
During maturation of oxytocin (OT) prohormone, several bioactive intermediate molecules are formed. The plasma concentrations of these forms (OT-G; OT-GK and OT-GKR) increase markedly in rat circulation at the end of gestation. At low concentration in the circulation OT stimulates while OT-GKR inhibits diuresis. Since OT and OT-GKR show different effects on the urine flow, we hypothesized that OT-GKR modulates renal action by targeting the V2 receptor.<p class="...